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has limited value in patients prepared with furosemide and hydration, and showed no statistically significant change in the detection rate (DR) of LR and the number of equivocal findings. Conclusion: Early static imaging additional to 68Ga-PSMA-11 PET images acquired 60 min p.i. The median SUVmax for bladder activity was 2.5 (range, 0.9–12.2) in the early scans and 8.2 (range, 1.8–27.6) in the scans 60 min p.i. The median SUVmax was 4.9 (range, 2.0–55.2) for positive lesions in the early scans and 8.0 (range, 2.1–139.9) in the scans 60 min p.i. Furthermore, the combination of both scans showed no statistically significant differences for the positive and negative findings ( p = 0.063).
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There was no statistical significance between the number of positive ( p = 0.815), negative ( p = 0.327), and equivocal ( p = 0.152) findings.
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For combined image analysis, 33 (17.4%) cases were positive and 20 (10.5%) were equivocal. Results: Image assessment resulted in 30 (15.8%) positive, 17 (8.9%) equivocal, and 143 (75.3%) negative findings in early scans, and 28 (14.7%) positive, 25 (13.2%) equivocal, and 137 (72.1%) negative findings of LR in 60 min p.i. The results were compared, and the combination of early and 60 min p.i. The scans were characterized as negative, positive, or equivocal. Assessment was based on visual analysis and calculation of the maximum standardized uptake value (SUVmax) of the pathologic lesions present in the prostate fossa found in the early PET imaging and 60 min PET scans. at the time of tracer application, followed by intravenous hydration with 500 mL of sodium chloride (NaCl 0.9%). (range, 45–100 min)) with intravenous administration of 20 mg furosemide i.v. (range, 56–923 s)) and a whole-body scan 60 min p.i. Patients received an early static scan of the pelvic area (median, 248 s p.i. Materials and Methods: 190 image sets of patients with BR in PCa who underwent 68Ga-PSMA-11 PET/CT were assessed retrospectively (median prostate specific antigen (PSA) value, 0.70 ng/mL (range, 0.1–105.6 ng/mL)). The aim of this study was to evaluate the diagnostic performance of early 68Ga-PSMA-11 PET imaging in comparison to 68Ga-PSMA-11 PET imaging 60 min post-injection (p.i.) in the detection of LR in patients with biochemical recurrence (BR) of prostate carcinoma. Background: 68Ga-PSMA-11 PET/CT is a promising method for the assessment of local recurrence (LR) in prostate cancer (PCa) patients.